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Neurons activated by the psychedelic 5-MeO-DMT light up across an entire hemisphere of the mouse brain.

Psychedelics and Non-Hallucinogenic Analogs Work Through the Same Receptor, Up to a Point

  • by Greg Watry
  • August 04, 2025
  • Science & Technology
  • News & Noteworthy
In new research led by the University of California, Davis, researchers found that non-hallucinogenic versions of psychedelic drugs promote neuroplasticity through the same biochemical pathway as psychedelics. However, unlike psychedelics, they don’t activate genes long thought to be key players in that process.
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